Paula Clemens, MD

Veterans Health Foundation

Paula Clemens, MD

Dr. Clemens joined the VA Pittsburgh Healthcare System in 1998 as a staff physician and researcher. She has had a faculty appointment at the University of Pittsburgh since 1995 and is currently Professor of Neurology and Vice Chair of Neurology. She assumed the position of Chief of the Neurology Service in the Medicine Service Line at VAPHS in 2004. Her clinical and research expertise are in neuromuscular disease, with a specific focus on genetic muscle diseases. Dr. Clemens collaborates with researchers at the University of Pittsburgh and other centers around the world to pursue translational research developing novel treatments for muscular dystrophy.


Department of Neurology, University of Pittsburgh School of Medicine

What are the most important questions that define your research program?

  • Can we develop treatments to prevent or ameliorate the skeletal muscle degeneration caused by muscular dystrophy?
  • Can we develop novel treatments for late-onset Pompe disease?
  • What are downstream mechanisms of skeletal muscle degeneration in muscular dystrophy and inflammatory myopathy?

What are examples of technologies, models, methods, analytical approaches or other forms of expertise that characterize your research program?

  • Histology
  • Biochemical studies (eg. Western blot)
  • EMSA
  • Mixed-effect statistical modeling
  • Muscle function and strength assessments