Jie Fan, M.D.

Veterans Health Foundation

Jie Fan, M.D.

Investigator Research Interests


  • Research Investigator, Director of Surgical Research, VA Pittsburgh Healthcare System
  • Professor of Surgery (General/Trauma/Acute Care Surgery), University of Pittsburgh

What are the 3 most important questions that define your research program?

  1. How does trauma promote the development of multiple organ dysfunction syndrome (MODS) In patients?
  2. How does trauma regulate immunity?
  3. Can we prevent trauma patients from developing MODS?

What are five key words that best describe your areas of interest?

  1. Acute lung injury
  2. Inflammatory signaling
  3. Innate immune cells interaction
  4. Cell death
  5. Cell priming

What are up to 5 technologies, models, methods, analytical approaches or other forms of expertise that characterize your research program?

  1. Animal models of trauma and inflammation
  2. Primary cell models of cell-cell interaction
  3. Intracellular molecule imaging
  4. In vivo innate immune cell depletion and repletion
  5. Flowcytometry