Dr. Fan has long been focusing on cellular and molecular mechanisms of cell priming in sepsis and organ injury after hemorrhagic shock. His team has explored a number of novel mechanisms of receptor crosstalk and cell-cell interaction underlying post-shock systemic inflammation and lung injury, and has been featured in numerous publications. The ongoing research projects in Dr. Fan’s lab include several lines that aim to elucidate the mechanisms of hemorrhagic shock-induced activation of inflammasome, pyroptosome, and autophagy in innate immune cells, as well as the significances of the resultant alterations in the development of post-hemorrhage systemic inflammatory response syndrome.