Steven H. Graham, M.D., Ph.D.

Veterans Health Foundation

Steven H. Graham, M.D., Ph.D.

Investigator Research Interests


  • Associate Chief of Staff for Research, VA Pittsburgh Healthcare System
  • Director, Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System
  • Professor and Vice-chair for Research, Department of Neurology, University of Pittsburgh

What are the 3 most important questions that define your research program?

  1. Role of UCH-L1 in neuronal function: ubiquitin proteasome system, axonal transport and synaptic function
  2. Effect of covalent modification of UCHL1 by reactive lipid species
  3. Role of UCHL1 in injury and recovery from cerebral ischemia, traumatic brain injury, neurodegenerative diseases and aging.

What are five key words that best describe your areas of interest?

  1. Ubiquitin-proteasome system
  2. Reactive lipid species
  3. Cerebral ischemia
  4. Traumatic brain injury
  5. Neurodegenerative diseases

What are up to 5 technologies, models, methods, analytical approaches or other forms of expertise that characterize your research program?

  1. Primary neuronal cell culture
  2. Animal models of cerebral ischemia and TBI
  3. Transduction of neurons with in vivo and in vitro with HIV TAT-fusion proteins
  4. Lenti viral infection of neurons in vivo and in vitro