Dr. Graham’s research interests include neuronal cell death mechanisms in stroke, traumatic brain injury and neurodegenerative diseases. His basic science research concerns the role of oxidative stress and lipids in neuronal apoptosis and recovery after ischemia and trauma.  Specifically, much of Dr. Graham’s  research is currently focused on the role of cyclopentenone prostaglandins and other oxidized lipids in neuronal cell death and dysfunction. In recent years, these efforts have focused on the lipid modification of UCHL1 and its role in injury and recovery after stroke and TBI.   As Director of the Pittsburgh Geriatric Research Education and Clinical Center, he oversees a multidisciplinary center that conducts basic and clinical research in aging and aging-related diseases